Duophase

Conventional slow release tablets are manufactured based on technology platforms, which were established several years ago. These slow release tablets provide sustained action but have lower Cmax & AUC.

Original research Duophase Technology - a Biphasic Drug Release system, programs the tablet to provide initial surge of loading dose followed by timed release of the drug to ensure Zero Order release pattern. The zero order mechanism ensures that a steady amount of drug is released over time, minimizing potential peak / trough fluctuations and side effects, while maximizing the amount of time the drug concentrations remain within the therapeutic window (efficacy).

Initial surge releases 50% of the drug to provide prompt symptomatic relief. Subsequent timed delivery ensures release of remaining 50% of the drug at a rate adequate to ensure Zero Order release pattern.

Thus Duophase technology allows 8 hourly dosing instead of the conventional 4-6 hourly dosing.

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